Circa 2335 BC, Sargon of Akkad conquered all of Mesopotamia, uniting its inhabitants into the world's first empire and spreading its domination into ancient Iran, the Levant, Anatolia, Canaan and the Arabian Peninsula. There was increasing syncretism between the Sumerian and Akkadian cultures and deities, with the Akkadians typically preferring to worship fewer deities but elevating them to greater positions of power. The Sumerians remained largely dominant in this synthesised culture, however, until the rise of the Akkadian Empire under Sargon of Akkad circa 2335 BC, which united all of Mesopotamia under one ruler.
They created the first city-states such as Uruk, Ur, Lagash, Isin, Kish, Umma, Eridu, Adab, Akshak, Sippar, Nippur and Larsa, each of them ruled by an ensí.
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The Sumerians were advanced: as well as inventing writing, early forms of mathematics, early wheeled vehicles/ chariots, astronomy, astrology, written code of law, organised medicine, advanced agriculture and architecture, and the calendar. The Akkadian-speaking Semites are believed to have entered the region at some point between 3500 BC and 3000 BC, with Akkadian names first appearing in the regnal lists of these states c. By historical times they resided in southern Mesopotamia, which was known as Sumer (and much later, Babylonia), and had considerable influence on the Akkadian speakers and their culture. The Sumerians left the first records, and are believed to have been the founders of the civilization of the Ubaid period (6500 BC to 3800 BC) in Upper Mesopotamia. These peoples were members of various city-states and small kingdoms. The people of Mesopotamia originally consisted of two groups, East Semitic Akkadian speakers (later divided into the Assyrians and Babylonians) and the people of Sumer, who spoke Sumerian, a language isolate. The first evidence for what is recogniseably Mesopotamian religion can be seen with the invention in Mesopotamia of writing circa 3500 BC. The early religious developments of the region are unknown since they preceded the invention of writing. The very earliest undercurrents of Mesopotamian religious thought are believed to have developed in the first half of the sixth millennium BC, at the time people first began to permanently settle in Mesopotamia owing to improved irrigation. Mesopotamian religion finally declined with the spread of Iranian religions during the Achaemenid Empire and with the Christianization of Mesopotamia. The last stages of Mesopotamian polytheism, which developed in the 2nd and 1st millenniums BC, introduced greater emphasis on personal religion and structured the gods into a monarchical hierarchy with the national god being the head of the pantheon. In the 3rd millennium BC objects of worship were personified and became an expansive cast of divinities with particular functions. The earliest evidence of Mesopotamian religion date to the mid-fourth millennium BC, coinciding with the invention of writing, and involved the worship of forces of nature as providers of sustenance. The earliest undercurrents of Mesopotamian religious thought are believed to have developed in Mesopotamia in the sixth millennium BC, coinciding with the region beginning to be permanently settled. Rather, Mesopotamian religion was a consistent and coherent tradition which adapted to the internal needs of its adherents over millennia of development. The religious development of Mesopotamia and Mesopotamian culture in general, especially in the south, was not particularly influenced by the movements of the various peoples into and throughout the area. Mesopotamian religion refers to the religious beliefs and practices of the civilizations of ancient Mesopotamia, particularly Sumer, Akkad, Assyria and Babylonia between circa 6000 BC and 400 AD, after which they largely gave way to Syriac Christianity practiced by today's Assyrians.